Posted to MedZilla HealthCare on 12/9/2018

Takeda Pharmaceuticals

US-CA, Scientist II, Biophysics - San Diego, CA R0003834-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Scientist II, Biophysics in our San Diego office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Scientist II, Biophysics on the Structured Biology and Biophysics team, you will be empowered to proactively identify opportunities for ITC, SPR and other technologies to investigate soluble and membrane proteins.


  • The Scientist II, Biophysics independently implements biophysics strategies to study protein interactions with small molecule ligands and biomolecules. Scientist IIis well-versed in the use of SPR and other biophysics approaches for hit identification, validation, and lead optimization. Associate Scientist has a track record of determining thermodynamic and kinetic parameters governing protein binding and has a deep understanding of membrane proteins and biologics.
  • The Scientist II, Biophysics will work closely with structural biologists, chemists, and biologists in preclinical research projects and will be responsible for providing effective and innovative solutions to address program-specific needs and challenges. Scientist II, Biophysics also leads external collaborators with private and academic institutions to outsource research and provide access to skills, resources and capabilities that supplement Takeda s.


  • Manage the design, development, and implementation of experiments to support drug discovery projects and characterizes small molecule and antibody interactions with membrane proteins.
  • Proactively identify opportunities for SPR and other technologies to investigate soluble and membrane proteins
  • Work closely with other biophysicists in the team to develop integrative approaches to address specific challenges and bottlenecks.
  • Lead the identification and utilization of current and emerging biophysical technologies for use internally or accessed via external partners that will favorably impact projects.
  • Identify opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities. Leads and manages external collaborations effectively.
  • Work closely with the Structural Biology and Biophysics Group to develop integrative approaches to address specific challenges and bottlenecks.
  • Participate on cross-functional teams and provides technical leadership in the areas of biophysics.
  • Effectively present data to other scientific staff and cross-functional project teams; may present data/posters to external research or scientific community.


  • Biochemistry, Biophysics, or related discipline with 2+ relevant years in a research and/or development environment, or MS degree with at least 8+ years of biophysics experience, or BS degree with at least 10+ years of biophysics experience, and a demonstrated working knowledge of biophysics scientific principles, or equivalent.
  • Demonstrated experience with biophysical techniques including, TSA, SPR, ITC, DLS, and fluorescence spectroscopy.
  • Demonstrates fundamental understanding of drug discovery within one or more areas.
  • Experience in the study of membrane proteins and antibody-antigen interactions as well as a good understanding of other biophysical techniques like MS and NMR.
  • Strong track record for studying protein interactions and macromolecular complexes as evidenced by quality and quantity of publications/presentations/inventions.
  • Familiar with other structural biology methods like X-ray crystallography, NMR spectroscopy and electron microscopy.
  • Experience with preparation of high-quality protein samples for biophysics studies.
  • Good team player with positive attitude and strong collaboration skills including the ability to work individually as well as part of an effective team.
  • Highly motivated and flexible with the ability to work in a fast-paced environment. Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
  • Detail oriented and with very high scientific standards.
  • Demonstrated interest in applying biophysics strategies to fragment based drug discovery.\
  • Proven track record of scientific contributions in life science as evidenced by quality and quantity of publications/presentations/inventions and/or products and clinical candidates
  • Excellent verbal and written communication skills.
  • Ability to work in fast-paced, collaborative, team-oriented environment.
  • Ability to provide novel creative solutions to challenging problems.
  • Desire to learn and tackle new challenges and initiatives.
  • Professionally represents Takeda in collaborations, partnership discussions, and external relationships and conferences.


  • Use hands on a regular basis to handle small laboratory equipment, including multi-channel pipettors, for liquid transfers to and from 96- and 384-well plastic assay plates.
  • Able to lift or move up to 10 pounds on a regular basis in the course of daily work.
  • Exposure to hazardous/toxic/dangerous chemicals.


  • Less than or equal to 5% travel, consisting of one to two relevant scientific meetings and/or trips to meet with collaborators and CROs


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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San Diego, CA

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Full time

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