Posted to MedZilla HealthCare on 11/19/2018

Takeda Pharmaceuticals

US-MA, Director / Associate Director, Immunology - Next Generation Biology Group - GI DDU R0000414-MZ


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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Associate Director / Director, Immunology - Next Generation Biology Group - GI DDU- in our Cambridge office.
Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As an Associate Director / Director, Immunology - Next Generation Biology Group working on the Gastroenterology Drug Discovery Unit team, you will be empowered to work cross-functionally with Data Science and Immunology divisions and contribute towards GI drug pipeline, and a typical day will include:
POSITION OBJECTIVES:The immunologist will join the next generation biology (NGB) group in GI Drug Discovery Team which collaborates with multiple stake holders within and outside of Takeda to identify novel drug targets via internal research and external collaboration with biotech and academic partners for gastrointestinal diseases. In addition, to early target discovery and prosecution, members of the NGB group will provide scientific project and strategic leadership for immunology drug candidates through IND in collaboration with Translation Research and Early Target (TREC) discovery at Takeda. The NGB group is a growing interdisciplinary group tasked with bringing the next wave of novel targets and approaches including cellular/gene therapy for gastrointestinal diseases such as inflammatory bowel disease, liver and enteric nervous system diseases. The NGB group expertise will encompass expertise in computational biology, engineering, regenerative medicine, synthetic biology/chemistry and immuno-biology. We are looking for a dynamic and driven individual join our growing group as an expert in mucosal immunology with an emphasis on neuro-immunology and microbiome-host interactions. The individual we are seeking will be an integral part of the drug discovery process as key leader to deliver on our goals as part of the larger GI Drug Discovery Unit (GI-DDU) composed of a matrixed group of approximately 80 individuals including our GI Immunology group based in San Diego. The AD/Director of Immunology will have wide visibility within the organization and among our academic and biotech partners.


  • Collaborates closely with GI Immunology researchers in San Diego as a scientific lead and/or advisor on internal immunology research programs involving small molecule, biologics, and/or novel modalities.
  • Acts as the scientific/ project lead for Takeda in our external biotech partnerships focused on therapies for GI immunological disorders such as inflammatory bowel disease.
  • Acts as the scientific/ project lead for Takeda in our academic partnerships focused on therapies or novel target ID for GI immunological disorders
  • Develop human first novel target ID approaches for our immunology programs using human data sets.
  • Supporting clinical translation and biomarker programs in collaboration with TREC colleagues.
  • Collaborates closely with GI Immunology researchers in San Diego site to help achieve the GI Drug Discovery strategic goals and approaches helping to establish and meet timelines and build go/no-go decision points on pipeline.
  • Drives a strategy to identify novel targets and cutting edge research programs on microbiome-host interactions and/or neuro-immunology using genomic approaches including single cell functional analytics, synthetic biology, and cellular engineering as well as aid in developing genetic screens using primary cells and CRISPR tools.
  • Establishes rapport & collaborates with scientific leaders, KOLs, academic partners, CROs and is seen as an international subject matter expert in Immunology research and therapeutics.
  • Responsible for identifying partnerships with emerging biotech to establish partnerships to identify drug targets and/or license innovative early development leads in collaboration with our business development colleagues.


  • PhD or MD/PhD in immunology with a focus on mucosal biology of the GI tract. An emphasis of host-microbiome interactions and/or neuro-immunology of the enteric nervous system is a plus. In addition, demonstrated screening experience a plus but not necessary.
  • 5-10 years of large pharma or biotech experience although a junior professor at a top tier academic institution with some industry experience (minimum of 2 years) would be considered.
  • Postdoctoral work carried out in world-renowned Immunology lab
  • Publication record in top scientific journals (International reputation)
  • Track record of contributing to progression of immunology programs ranging from target discovery to clinical proof-of-concept in an industry setting
  • Demonstrated creativity in scientific approaches and questions addressed
  • Experience in managing teams in a matrix environment
  • Experience in building and supporting partnerships with academic institutions and/or companies


  • The position is base in Cambridge, MA.
  • Requires approximately 15-20% or more travel, including international travel.


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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Cambridge, MA

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