Posted to MedZilla HealthCare on 1/19/2018

Takeda Pharmaceuticals

US-MA, Translational Research Lead, Cold to Hot - Tumor Microenvironment 1703325-MZ


Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Translational Research Lead, Cold to Hot in our Cambridge office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As aTranslational Research Lead working on the Oncology Biology team, you will be empowered to supervise a team of translational scientist to formulate translational blueprints and actively contribute to the design and execution of mechanism-of-action and proof of concept studies, and a typical day will include:

Based in Cambridge, MA, this senior leader will be responsible for overseeing translational research support for all Oncology programs under the cold-to-hot tumour microenvironment strategic pillar for immuno-oncology at Takeda, focused on next-gen modulators of immune checkpoints, innate immunocytes, and tumour microenvironment intended to elicit durable immune responses to susceptible cancer subtypes. This leader will supervise a team of translational scientists who will work closely with Research and Development project teams to formulate translational blueprints and to enable execution of robust, decision-enabling preclinical and reverse-translation experiments to inform the clinical precision medicine strategy leading to early proof-of-concept, to maximize expansion opportunities for clinical assets, and to leverage clinical learning for discovery of new therapeutic approaches. The leader is expected to actively contribute to the design and execution of (i) mechanism-of-action and (ii) proof-of-concept studies in close partnership with colleagues in O-TAU, DMPK and TREC.

  • Reports to the head of the Translational Sciences within the Oncology Drug Discovery Unit (ODDU)
  • Contributes to building a robust preclinical and clinical immuno-oncology pipeline within the cold-to-hot tumour microenvironment strategic area by leading in a matrixed, externally facing environment
  • Directly supports multiple discovery-stage programs by defining and executing the translational data package to enable the precision medicine strategy for early clinical proof-of-concept
  • Directly supports multiple development-stage programs (pre-IND through life-cycle management) by defining and executing the preclinical translational research to inform pivotal decision points and to maximize asset value
  • Collaborates closely with other key line functions within the Oncology therapeutic area at Takeda and with key partners in Takeda, including DMPK and TREC
  • Establishes and manages project-specific and broad academic research collaborations
  • Works closely with in-house and external partners in developing translational research plans, in interpreting results, and in determining next steps
  • Designs and drives the reverse translational strategy for Oncology research in the cold-to-hot strategic area
  • Manage a small team of experienced scientists who will be accountable for supporting their own discovery and development programs as translational researchers


  • PhD or MD in relevant field of biomedical research
  • A senior researcher with 10+ years of relevant industry experience in drug development and with extensive experience in oncology discovery, early clinical development and translational biology
  • Recognized expert in immuno-oncology in general and specifically in B, T, NK, dendritic and macrophage biology
  • Experienced in preclinical and clinical biomarker research
  • Capable of leading and executing research within a matrixed environment comprising internal / external resources
  • Outstanding interpersonal skills, leadership abilities, and oral and written communication
  • Exceptional analytical and strategic skills


  • Requires approximately 15% business travel, including international


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

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